By Christos C. Zouboulis
Dermatological examine has skilled a quick improvement within the final twenty years, besides the fact that, it has infrequently all in favour of the endocrine capabilities of the surface. just a couple of years in the past clinicians and researchers in dermatology began to discover the surface as a goal organ for many hormones. within the final years the outside has been well-known because the biggest endocrine, paracrine and autocrine organ of the physique. it can metabolize steroid hormones and to provide derivatives with in all likelihood systemic task. issues of hormone metabolism can both result in direct results at the dermis or ultimately disturb dermis homeostasis. Endocrine dermatology is a brand new and interesting sector of epidermis learn. It contains dermis ailments because of or linked to endocrine problems, epidermis problems which might be handled with hormones or with compounds with hormone-like job, and epidermis problems which happen as hostile occasions of hormone remedy or of remedy with compounds showing a hormone-like impression.
Read or Download Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6) PDF
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Additional resources for Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6)
Histopathology reveals multiple subcapsular follicular cysts, cortical thickening and increased stromal tissue. In severe cases, enlarged ovaries with hyperthecosis and large persistent follicular cysts can be detected by sonography. The patients are usually young women with significant seborrhea, inflammatory scarring acne, mammary, lateral facial and central body hirsutism, and androgenetic alopecia. Young females can be obese or have a tendency to obesity with regular menses or suffer from oligo- or amenorrhoea and virilization .
In marked contrast neither axillary nor pubic cells  contained significant amounts of 5·-dihydrotestosterone intracellularly even when cultured for 24 h (fig. 3). This again reflects hair growth in men with 5·-reductase deficiency where the female patterns of pubic and axillary hair are evident. It is possible that these follicles are so much more sensitive to androgens than beard and other male sexual characteristic hair follicles that there is sufficient 5·-dihydrotestosterone circulating as a result of 5·-reductase type 1 activity to stimulate pubic and axillary hair growth.
Pathogenetic Background Women produce androgens in the ovaries, the adrenal glands and also in peripheral organs, especially the skin, the skeletal muscles and the liver . The ovaries secrete Copyright © 2001 S. Karger AG, Basel ABC © 2001 S. com/journals/hre Prof. Dr. Christos C. Zouboulis Department of Dermatology, University Medical Center Benjamin Franklin The Free University of Berlin Fabeckstrasse 60–62, D–14195 Berlin (Germany) Tel. de Fig. 1. Synthesis of the two major circulating androgens, androstenedione and testosterone [from ref.
Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6) by Christos C. Zouboulis