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During TGF-ß l-induced stimulation, both aland a2 Ig germline transcripts are produced. 12 Whether germline a2 transcripts are synthesized in IgM+ cells, or whether they are limited to B Iymphocytes that already have undergone a switch recombination to a 5' duplicated locus (y3, yl, and al) gene segment remains to be shown. 1 could serve as useful tools in deciphering these alternatives. ACKNOWLEDGMENTS This work was supported by the Swedish Medical Research Council, the Ake Wiberg Foundation and the HesseIman Foundation.

Sterzl and L. Mandel, Folia Microbiol. 9: 173 (1964). J. Sterzl, in: "Highlights In Modern Biochemistry", Vol. 2, A. , p. 1277, VSP, Utrecht (1989). E. Smith,1 B. Baskin,1 E. Pattersson,2 L. B. Islam 1 1Center for Biotechnology, Karolinska Institute at Novum, S-141 57 Huddinge and Department of Clinical Immunology 2Department of Nephrology, Karolinska Institute at Huddinge Hospital, S-141 86 Huddinge, Sweden INTRODUCTION Transforming growth factor ßI (TOF-ßl) induces the earliest known steps of isotype switching to IgA in humans.

1225 S. Husby, J. Mestecky, Z. O. Elson ORAL TOLERANCE TO OVALBUMIN IN MICE: EFFECT OF SOME PARAMETERS ON THE INDUCTION AND PERSISTENCE OF THE SUPPRESSION OF SYSTEMIC IgE AND IgG ANTffiODY RESPONSES ................................................................................. C. Moreau, M. Coste,V. Gaboriau, and C. Dubuquoy EVIDENCE OF A DIRECT ROLE FOR MUCOSAL IMMUNE CELLS IN THE INDUCTION OF ORAL TOLERANCE......... ............................... 1235 E. Furrie, M. Turner, and S. Strobel THE ABSENCE OF GUT FLORA HAS NO EFFECT ON THE INDUCTION OF ORAL TOLERANCE TO OV ALBUMIN...........................

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Aplicaciones Ortodвnticas en Implantes

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