A mutation-selection model with recombination for general - download pdf or read online

By Steven N. Evans

ISBN-10: 0821875698

ISBN-13: 9780821875698

ISBN-10: 4400057283

ISBN-13: 9784400057284

The authors examine a continual time, likelihood measure-valued dynamical approach that describes the method of mutation-selection stability in a context the place the inhabitants is countless, there's infinitely many loci, and there are susceptible assumptions on selective expenses. Their version arises once they contain very normal recombination mechanisms into an previous version of mutation and choice provided by means of Steinsaltz, Evans and Wachter in 2005 and take the relative energy of mutation and choice to be small enough. The ensuing dynamical procedure is a move of measures at the area of loci. every one such degree is the depth degree of a Poisson random degree at the house of loci: the issues of a realisation of the random degree checklist the set of loci at which the genotype of a uniformly selected person differs from a reference wild variety because of an accumulation of ancestral mutations. The authors' motivation for operating in any such basic surroundings is to supply a foundation for realizing mutation-driven alterations in age-specific demographic schedules that come up from the complicated interplay of many genes, and as a result to enhance a framework for figuring out the evolution of getting older

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5) S(g) = 1 − exp − θ(m) dg(m) M for some θ : M → R+ . Moreover, in this case it is possible to analyze whether limt→∞ ρt exists, and we couple this analysis with a comparison argument in later sections to give sufficient conditions for the existence of a limit for more general selective costs. 30 3. EQUILIBRIA Suppose that ρ0 is absolutely continuous with respect to ν. 10 that the measure ρt has a Radon-Nikodym derivative m → rt (m) against ν for all t ≥ 0 such that for each m ∈ M the function t → rt (m) is continuously differentiable and solves the equation drt (m) = 1 − E[S(X ρt + δm ) − S(X ρt )] rt (m).

Then, for any Borel set A, the quantity ρt (A) is increasing in t and bounded by R, so it converges to a limit ρ∗ (A). It is easy to check that A → ρ∗ (A) is a measure in H+ and that ρt converges to ρ∗ in the Wasserstein metric (that is, in the topology of weak convergence). 10) we know that for any Borel set A, and any s < t, t ν(A) − D ρu (A) du, 0 ≤ ρt (A) − ρs (A) = s where the operator D is the analogue of the operator D when the selective cost S is replaced by the selective cost S . We conclude that ν(A) − D ρu (A) ≥ 0 for all u ≥ 0, and so ρ∗ (A) − ρt (A) = ∞ ν(A) − D ρu (A) du ↓ 0 as t → ∞.

Fix u ∈ [0, U ). The dynamical system with mutation measure U ν converges to a finite equilibrium p(U) ν ∈ H+ , where p(U) ≥ p(u) . Let (ρt )t≥0 be the dynamical system with mutation measure U ν started from ρ0 = p(u) · ν and let (ρt )t≥0 be the dynamical system with mutation measure uν started from ρ0 = p(U) · ν. Thus, (ρt )t≥0 starts below its equilibrium, and (ρt )t≥0 starts above its equilibrium. We have ρ˙ 0 = uν − Fp(U ) ν p(U) · ν = (u − U )ν ≤ 0, ρ˙ 0 = uν − Fp(u) ν p(u) · ν = (U − u)ν ≥ 0.

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A mutation-selection model with recombination for general genotypes by Steven N. Evans


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